Cheke may refer to:
People Henry Cheke (c. 1548–1586), English politician John Cheke (1514–1557), English classical scholar and statesman; husband of Mary Cheke Mary Cheke (c. 1532-1616), English lady of the privy chamber, courtier poet, epigrammatist; wife of John Cheke
Fauna Cheke's day gecko, subspecies of day gecko, a lizard in the family Gekkonidae Cheke's wood rail, extinct species of rail which was endemic to the Mascarene island of Mauritius
Other Cheke Holo language, Oceanic language spoken in the Solomon Islands