ISCA or Isca may refer to:

ISCA, a four letter abbreviation which may be one of: ISCABBS, a bulletin board system at the University of Iowa Indian Science Congress Association International Sea Cadet Association Islamic Supreme Council of America International Symposium on Computer Architecture International Scouting Collectors Association International Speech Communication Association International Sport and Culture Association Institute of Singapore Chartered Accountants International Society of Caricature Artists International Society of Copier Artists Israeli Students Combating Antisemitism Infrastructure Sustainability Council of Australia International Security Conference on Africa

Isca, any of several places in Roman Britain, derived from a Brythonic word for "flowing water": Isca Dumnoniorum, modern Exeter Isca Augusta, modern Caerleon Isca, the River Usk

Isca, a place in Calabria, Italy: Isca sullo Ionio Isca Marina

Other meanings: Isca, a village in Meteș Commune, Alba County, Romania Alternate transliteration of Iscah, daughter of Haran Isca Academy Isca Hockey Club Isca the Unbeaten, Marvel Comics character

See also Iska (disambiguation)