Karlstrøm is a surname. Notable people with the surname include:
Åshild Karlstrøm Rundhaug (born 1955), Norwegian politician Cornelius Karlstrøm (1897–1978), Norwegian politician Jacob Karlstrøm (born 1997), Norwegian footballer Randi Karlstrøm (born 1960), Norwegian politician Steinar Karlstrøm (born 1965), Norwegian politician
See also Karlström