Holtsmark is a surname. Notable people with the surname include:
Anne Holtsmark (1896–1974), Norwegian philologist Bent Holtsmark (1823–1903), Norwegian politician Bernt Holtsmark (1859–1941), Norwegian politician Gabriel Gabrielsen Holtsmark (1867–1954), Norwegian educator, physicist and actuary Johan Peter Holtsmark (1894–1975), Norwegian physicist Karen Holtsmark (1907–1998), Norwegian painter Torger Holtsmark (1863–1926), Norwegian politician