This is an incomplete list of unsolved murders in the United Kingdom that were committed before 1970, the earliest being in 1536. The list excludes any murders in Northern Ireland related to The Troubles, or that are related to IRA bombings which occurred in England.

Victims believed to have been killed by the same perpetrator(s) are grouped together below.

Before 1800 Year Victim(s) Location of body or bodies Notes1536Robert PakingtonLondonThe slaying of Pakington was considered the first instance of murder committed using a handgun in London.1678Edmund Berry GodfreyPrimrose HillGodfrey was strangled and posthumously impaled on his own sword. Both killer(s) and motive(s) are unknown.1752Colin Roy Campbell of GlenureAppin, ArgyllKnown as the Appin Murder, the murder of Colin Roy Campbell of Glenure took place at Appin, in the west of Scotland, in the aftermath of the Jacobite rising of 1745. It inspired events in Robert Louis Stevenson's novel Kidnapped.1759George BurringtonSt. James's Park, WestminsterThe body of Burrington, former Governor of North Carolina, was retrieved from the canal in St. James's Park on 22 February 1759. He had been beaten and robbed.

1800–1899