Uppalapati (Telugu: ఉప్పలపాటి) is a Telugu surname. Notable people with the surname include:
Prabhas (born as Uppalapati Venkata Satyanarayana Prabhas Raju, 1979), Indian actor Uppalapati Surya Narayana Raju (died 2010), Telugu producer Krishnam Raju (born as Uppalapati Venkata Krishnam Raju, 1940), Indian actor and politician Uppalapati Narayana Rao (born 1958), Indian director, screenwriter, scriptwriter, actor and producer