Senator Nicholson may refer to:
Alfred O. P. Nicholson (1808–1876), U.S. Senator from Tennessee from 1840 to 1842; also served in the Tennessee State Senate Donald W. Nicholson (1888–1968), Massachusetts State Senate Elwyn Nicholson (1923–2014), Louisiana State Senate Floyd Nicholson (born 1949), South Carolina Senate Isaac R. Nicholson (1789/90–1844), Mississippi State Senate Jeanne Nicholson (born 1952), Colorado State Senate Samuel D. Nicholson (1859–1921), U.S. Senator from Colorado from 1921 to 1923