The 1933 Louisville Cardinals football team was an American football team that represented the University of Louisville as a member of the Southern Intercollegiate Athletic Association (SIAA) during the 1933 college football season. In their first season under head coach Ben Cregor, the Cardinals compiled a 1–7 record.
Louisville's 1933 season was part of a 24-game losing streak dating back to October 2, 1931. The streak ended on November 18 with a 13–7 victory over .
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