2005–06 Eerste Klasse was a Dutch association football season of the Eerste Klasse.
Saturday champions were: A: SV Huizen B: TOGR C: SSV '65 D: VV Nunspeet E: Oranje Nassau Groningen
Sunday champions were: A: HVV Hollandia B: VUC Den Haag C: Blauw Geel '38 D: RKSV Groene Ster E: SC Enschede F: Meppeler Sport Club