Jacobsohn is a surname. Notable people with the surname include:
Boris Jacobsohn (1918–1966), American physicist Dora Jacobsohn (1908–1983), German-Swedish physiologist and endocrinologist Friedrich Jacobsohn (1894–?), German urologist and writer Helen Jacobsohn (born 1945), Australian sprint canoeist Margaret Jacobsohn, Namibian environmentalist Siegfried Jacobsohn (1881–1926), German journalist, editor and theatre critic Simon E. Jacobsohn (1839–1902), Latvian-American violinist
See also Bekhterev–Jacobsohn reflex, Medical sign