de la O is a surname of Spanish origin, and may refer to:
Marco de la O (born 1978), Mexican actor Rogelio Ramírez de la O (born 1948), economist based in Mexico City Valentino de la O, host of the Val De La O Show Genovevo de la O (1876–1952), figure in the Mexican Revolution in Morelos
See also María de la O is a given name.