Szpiro is a Polish Jewish surname, a variant of Shapiro. Notable people with this surname include:
Abram Szpiro (1912-1943), Polish chess master Dawid Szpiro (1922-1944), Hashomer Hatzair resistance member killed by the Gestapo (see Holocaust Encyclopedia entry) George Szpiro (born 1950), Israeli-Swiss author, journalist, and mathematician Lucien Szpiro (1941–2020), French mathematician Szpiro's conjecture, formulated by Lucien Szpiro
See also Shapiro, main article on Ashkenazi Jewish surname with Szpiro as one of many variants Szapiro