Otzen is a surname. Notable people with the surname include:
Christina Otzen (born 1975), Danish sailor Per Marquard Otzen (born 1944) Danish Editorial Cartoonist, Politiken Johannes Otzen (1839–1911), German architect, urban planner, architectural theorist, and university teacher Robert Otzen (1872–1934), German infrastructure engineer Volmer Otzen, Danish diver