Senator Holmes may refer to:
Members of the United States Senate David Holmes (politician) (1769–1832), U.S. Senator from Mississippi from 1820 to 1825 John Holmes (Maine politician) (1773–1843), U.S. Senator from Maine from 1820 to 1827
United States state senate members David S. Holmes Jr. (1914–1994), Michigan State Senate Ezekiel Holmes (1801–1865), Maine State Senate John Bee Holmes (1760–1827), South Carolina State Senate Linda Holmes (born 1959), Illinois State Senate Mitch Holmes (born 1962), Kansas State Senate Newland H. Holmes (1891–1965), Massachusetts State Senate Patricia Holmes (politician) (born 1959), Michigan State Senate Robert D. Holmes (1909–1976), Oregon State Senate Sybil Holmes (1889–1979), Massachusetts State Senate