Syke or SYKE may refer to:
Places Syke, a town in Lower Saxony, Germany Syke (Cilicia), a town of ancient Cilicia
People Big Syke (1968–2016), American rapper Syke Pachino (born 1978), Spanish-American hip-hop artist
Other uses Syke (TV series), a Finnish television series Syke or sike, term for ravine or narrow valley in parts of the UK Syke railway station, serving Syke, Germany Finnish Environment Institute () Fountain (heraldry), a roundel
See also Sike (disambiguation)