MP2 or MP-2 may refer to:
Aviation The second terminal of Marseille Provence Airport Chyetverikov ARK-3 flying-boat
Firearms German Army designation for the Uzi MP-2 machine pistol
Science MP 2, an abbreviation for a zone during the Paleocene Møller–Plesset perturbation theory of the second order, a method in the field of computational chemistry
Technology File formats MPEG-1 Audio Layer II, a lossy audio compression format MPEG-2, a video encoding standard
Video games Mario Party 2, a 1999 party game for the Nintendo 64 and the second game for the console Max Payne 2: The Fall of Max Payne, a 2003 shooter game Metroid Prime 2: Echoes, a 2004 action-adventure game