The U.S. state of Mississippi first required its residents to register their motor vehicles and display license plates in 1912. Since then, the state has gone through a variety of license plate designs and currently has several different designs for passenger, non-passenger, and optional-issue plates.

Plates are currently issued by the Vehicle Licensing Division of the Mississippi Department of Revenue. Only rear plates have been required since 1925.

Passenger baseplates 1912 to 1976 In 1956, the United States, Canada, and Mexico came to an agreement with the American Association of Motor Vehicle Administrators, the Automobile Manufacturers Association and the National Safety Council that standardized the size for license plates for vehicles (except those for motorcycles) at in height by in width, with standardized mounting holes. The first Mississippi license plate that complied with these standards was issued 22 years beforehand, in 1934.