The Plattsmouth Main Street Historic District, in Plattsmouth, Nebraska, is a historic district which was listed on the National Register of Historic Places in 1985. The listing included 45 contributing buildings on .
It is in the area of Main St. bounded by Avenue A, S. and N. 3rd St., 1st Ave. and S. and N. 7th St. in Plattsmouth.
It includes:
Cass County Courthouse (1892), 4th & Main Streets: brick, three-story building with a tower at each corner and a central tower . Designed by William Gray. Separately listed on the National Register. Excelsior Building (before 1885), 313 Main Street. Commercial Italianate. With
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