ISAM or Isam may refer to:
Technology ISAM, the IBM mainframe indexed sequential access method C-ISAM, a C language application programming interface MyISAM, a storage engine for MySQL ISAM (spaceflight), a spaceflight technology process (In-space Servicing, Assembly, and Manufacturing)
People Isam (name), list of people with the name Banu Isam, a former Berber Muslim dynasty
Organizations Institute for Sales and Account Management International Society of Addiction Medicine Hitchcock Institute for the Study of American Music at Brooklyn College International Society for Aerosols in Medicine
Others ISAM (album), an album by musician Amon Tobin The Iraqi Security Assistance mission, part of the Multi-National Security Transition Command – Iraq