David Holmes may refer to:
Academics David L. Holmes (1932–2023), American academic and historian of Anglicanism Dave Holmes (researcher) (born 1967), Canadian researcher and academic
Arts and entertainment David Holmes (musician) (born 1969), Northern Irish electronic musician and composer David Holmes, drummer and vocalist for Servant Dave Holmes (actor) (born 1971), American MTV VJ, television presenter, actor, and writer David Holmes (actor) (born 1981), British stuntman and actor in the Harry Potter films
Politics and government David Holmes (politician) (1769–1832), last governor of the Mississippi Territory and the first governor of the State of Mississippi, congressman from Virginia David Holmes (trade unionist) (1843–1906), British trade unionist Ronald Holmes (David Ronald Holmes, 1913–1981), British colonial government official David Holmes (journalist) (1926–2014), BBC political editor David S. Holmes Jr. (1914–1994), American politician in Michigan, David Holmes (diplomat), United States Department of State official
Sports Dave Holmes (American football) (1924–1999), American football player and coach Dave Holmes (sportscaster), American sportscaster David Holmes (businessman) (born 1935), Scottish businessperson, former Chairman of Rangers F.C. David L. Holmes (coach) (1887–1960), American college sports coach and athletics administrator