Mkhize is a surname. Notable people with the surname include:
Bertha Mkhize (1889–1981), South African teacher and businesswoman Emmanuel Mkhize (born 1989), South African cricketer Florence Mkhize (1932–1999), South African anti-apartheid activist Hlengiwe Mkhize (1952–2021), South African politician Linda Mkhize (1981–2018), South African rapper Nomhlangano Beauty Mkhize (1946–1977), South African activist Saul Mkhize (1935–1983), South African activist Senzo Mkhize (died 2016), South African politician Shauwn Mkhize, South African businesswoman and socialite Siphesihle Mkhize (born 1999), South African footballer Siphetho Mkhize, South African politician Thamsanqa Mkhize (born 1988), South African footballer Themba Mkhize, South African jazz musician Zweli Mkhize (born 1956), South African doctor and ANC politician Olwethu Mkhize (born 2002), political activist
See also Florence Mkhize (patrol vessel), operated by South Africa