John or Jon Isaac may refer to:
John Isaac (cricketer) (1880–1915), English cricketer John Isaac (photographer), Indian-born photographer and author based in New York City Jon Isaac or Jonathan Isaac (born 1997), American basketball player John Noel Laughton Isaac, a British solicitor and the first British serviceman to die during World War Two
See also John Isaacs (disambiguation) Isaac John (born 1988), former rugby league footballer