Mzamane is a surname, and may refer to:
Godfrey Mzamane (1909–1977), a novelist, literary historian, academic and intellectual pioneer Dumisani Mzamane (1932–1997), a medical doctor, South Africa's first black nephrologist Joab Mzamane (1920–1989), an agriculturalist and father of Sitembele Mzamane Joe Mzamane (1918–1993), an Anglican priest, mayor and father of Mbulelo Mzamane Mbulelo Mzamane (1948–2014), a South African author, poet, and academic Sitembele Mzamane (1952– ), a South African Anglican bishop