Shepardson is a surname. Notable people with the surname include:
John Shepardson (1729—1802), American settler Marge Shepardson, American politician Ray Shepardson (1897–1975), American baseball player Raymond K. Shepardson (1944–2014), American theatre restoration specialist and operator Rob Shepardson, American political consultant and marketing strategist Whitney Shepardson (1890–1966), American businessman and foreign policy expert Gunner Shepardson(2007), American rapper and singer