The 1980–81 DePaul Blue Demons men's basketball team represented DePaul University during the 1980–81 NCAA Division I men's basketball season. They were led by head coach Ray Meyer, in his 39th season, and played their home games at the brand new Rosemont Horizon in Rosemont. For the second year in a row the Blue Demons were a #1 seed in the NCAA Tournament. Once again DePaul lost in the second round, this time to St Joseph's 49–48.

Roster

Schedule and results

!colspan=12 style=| Regular season

!colspan=12 style=| NCAA Tournament

Source:

Rankings

Team players drafted into the NBA 1 1 Mark Aguirre Dallas Mavericks 2 38 Clyde Bradshaw Atlanta Hawks

References