Melsheimer is a surname. Notable people with the surname include:
Ernst Melsheimer (1897–1960), German lawyer Frederick Valentine Melsheimer (1749–1814), American entomologist and Lutheran clergyman Frederick Ernst Melsheimer (1782–1873), American entomologist Thomas M. Melsheimer, American lawyer and managing partner of Winston & Strawn LLP's Dallas office
See also Melsheimer FM-1, is an American single-seat, high-wing, FAI Open Class glider