Portuondo is a surname of Spanish origin. Notable people with the surname include:
Bartolo Portuondo (1893–1981), Cuban baseball player Emilio Núñez Portuondo (1898–1978), Cuban politician, lawyer and diplomat María M. Portuondo, American historian of science Omara Portuondo (born 1930), Cuban singer and dancer Yasser Portuondo (born 1983), Cuban volleyball player