Lüscher is a surname mainly occurring in Switzerland. Outside German-speaking Switzerland the form Luscher may occur. Notable people with the surname include:
Bettina Lüscher (born 1961), German journalist Christian Lüscher (born 1963), Swiss attorney and politician Christian Lüscher (neurobiologist) (born 1963), Swiss neurobiologist
Gustav S. Luscher (1856–1943), American businessman and politician Henry R. Luscher, American politician Ingeborg Lüscher (born 1936), German-Swiss artist Jonas Lüscher (born 1976), Swiss-German writer and essayist Martin Lüscher (born 1949), Swiss theoretical physicist Max Lüscher (1923–2017), Swiss psychotherapist Peter Lüscher (born 1956), Swiss alpine ski racer Rudolf Lüscher (born 1945), Swiss former wrestler Sara Lüscher (born 1986), Swiss orienteering competitor Susanne Lüscher, Swiss orienteering competitor Sven Lüscher (born 1984), Swiss footballer