Cozzarelli is a surname. Notable people with the surname include:
Giosue Cozzarelli (born 1989), Panamanian beauty queen, model, and YouTube celebrity of Italian descent Guidoccio Cozzarelli (1450–1517), Italian painter and miniaturist Nicholas R. Cozzarelli (1938–2006), American biochemist Cozzarelli Prize, named in honor of the above
Frank D. Cozzarelli (1930–1979), American Artist. Painter, sculptor, potter, pulp fiction book cover artist.