Castellucci is an Italian surname. Notable people with the surname include:
Cecil Castellucci (born 1969), American-born Canadian young adult novelist, indie rocker and director Giovanni Castellucci (born 1959), Italian businessman Lars Castellucci (born 1974), German politician Romeo Castellucci (born 1960), Italian theater director, playwright, artist and designer Salvi Castellucci (1608–1672), Italian painter Teddy Castellucci (born 1965), American film score composer