Van Horne is a Dutch surname occurring mainly in the United States and Canada.
List of people with the surname Archibald Van Horne (c. 1758–1817), American politician Charles Van Horne (1921–2003), Canadian politician Dave Van Horne, American baseball announcer Espy Van Horne (1795–1829), U.S. Representative from Pennsylvania Harriet Van Horne (1920–1998), American newspaper columnist and film/television critic Heidi Van Horne, American actress and model Herman van Horne (died 1156), Dutch bishop Isaac Van Horne (1754–1834), U.S. Representative from Pennsylvania James Van Horne (1935–2025), American economist and finance academic Jim Van Horne (born 1950), Canadian sports anchor Johannes Van Horne, physician and anatomist Keith Van Horne (born 1957), American football player in the National Football League Mahlon Van Horne (1840–1910), American minister, state legislator, and diplomat Randy Van Horne (1924–2007), American singer and Flintstones theme song creator Robert Van Horne (born 1948), American composer and concert pianist Robert Van Horne (American football), American football coach Ron Van Horne (1932–2017), Canadian politician Terry Van Horne (1946–2012), American politician William Cornelius Van Horne (1843–1915), Canadian railway executive
Fictional characters Melvin Van Horne, the real name of Sideshow Mel in The Simpsons Daryl Van Horne, the main antagonist of the 1987 fantasy-comedy The Witches of Eastwick (film). Played by Jack Nicholson.