EFCC may refer to:
Economic and Financial Crimes Commission, a Nigerian law enforcement agency Evangelical Free Church of Canada, a Canadian evangelical denomination Evangelical Free Church of China, a Hong Kong evangelical denomination, formerly active in mainland China Evangelical Fellowship of Congregational Churches, a British evangelical denomination Ellis Fischel Cancer Center, Columbia, Missouri, U.S. European Federation of Clinical Chemistry and Laboratory Medicine (EFLM, formerly EFCC)
See also EFCC1, EF-hand and coiled-coil domain containing 1, a humans gene Ministry of Environment, Forest and Climate Change (MoEFCC), is an Indian government ministry