Mary Burke (born 1959) is an American businesswoman.
Mary Burke may also refer to:
Mary Burke (basketball) (born 1965), American women's college basketball coach Marylouise Burke, American actress Mary Burke Washington (1926–2014), American economist Mary Griggs Burke (1916–2012), American art collector Mary Murray-Burke, Irish member of Crystal Swing Billie Burke (Mary William Ethelbert Appleton Burke, 1884–1970), American actress Mary Burke (consort) (c. 1560–c. 1627), Irish noblewoman and consort of Brian O'Rourke