Catherine (or variants) O'Brien may refer to:

Catherine Amelia O'Brien (1881–1963), Irish stained glass artist Catherine O'Brien (film scholar), British film scholar Catherine O'Brien (Neighbours) Katherine O'Brien, physician and scientist in the field of pneumococcal disease Katharine O'Brien, film director

See also

Kitty O'Brien (disambiguation) Cathy O'Brien (disambiguation) Kate O'Brien (disambiguation)