Ledwith is a surname. Notable people with the surname include:
Ann Ledwith, Irish engineer and academic administrator Anthony Ledwith (1933–2015), British chemist Martin Ledwith, British actor and acting coach Micheál Ledwith, Irish Roman Catholic priest Mike Ledwith (1874–1929), American baseball player Thomas A. Ledwith (1840–1898), American lawyer and politician