Polini is a surname. Notable people with the surname include:
Marcella Hazan (née Polini, 1924–2013), Italian cooking writer André Polini, Brazilian bicyclist, silver medalist at 2002 Pan American Road and Track Championships Battista Polini, founder of motorcycle parts company Polini Bella Polini, actress in 1922 German silent film Morass Claudia Polini, Italian-American mathematician Emélie Polini (1881–1927), English-Australian stage actress Marino Polini (born 1959), Italian bicyclist
Polini is also the name of a character in 1944 western film Arizona Whirlwind