Lesko or Leško is a surname. Notable people with the surname include:
Adrián Leško (born 1995), Slovak footballer Anna Lesko (born 1979), American singer Artur Lesko (born 1984), Belarusian footballer Dávid Leško (born 1988), Slovak footballer Debbie Lesko (born 1958), American politician Ján Leško (born 1986), Slovak footballer John Charles Lesko, American convicted spree killer Leonard H. Lesko (born 1938), American Egyptologist Marina Lesko (born 1968), Russian journalist Mark Lesko (born 1967), American politician Matthew Lesko (born 1943), American author Peter Leško (born 1991), Slovak footballer