DeMoss is a surname. Notable people with the surname include:
Bingo DeMoss (1889–1965), American baseball player Bob DeMoss (1927–2017), American football player Darcy DeMoss (born 1963), American actress Grace DeMoss (born 1927), American golfer Harold R. DeMoss Jr. (born 1930), American judge Hugh DeMoss (1932–2003), American journalist and politician Mary Hissem De Moss (1871–1960), American soprano singer Mickie DeMoss (born 1955), American basketball player and coach Nancy DeMoss Wolgemuth (born 1958), American Christian radio host and author