Kanellopoulos () is a Greek surname, meaning "son of Kanellos". The feminine form is Kanellopoulou (Κανελλοπούλου). Notable people with the surname include:
Angeliki Kanellopoulou (born 1965), Greek tennis player Kanellos Kanellopoulos (born 1957), Greek cyclist Maria Kanellopoulou (born 1977), Greek water polo player Panagiotis Kanellopoulos (1902–1986), Greek writer, politician and Prime Minister of Greece Takis Kanellopoulos (1933–1990), Greek film director and screenwriter