Grymes is a surname. Notable people with the surname include:
Aaron Grymes (born 1991), Canadian football player Charles Grymes McCawley (1827–1891), American military service member John Randolph Grymes (1786–1854), American politician Nahum Thorton Grymes, known as J. Holiday (born 1984), American singer Philip Grymes (c. 1777 – 1818), American lawyer
William Grymes Pettus (1794–1867), American politician