Medoff is a surname. Notable people with the surname include:
Jillian Medoff (born 1963), American author Kara Medoff Barnett (born 1978), American business executive, theatre producer and arts administrator Mark Medoff (1940–2019), American playwright, screenwriter, film and theatre director, actor and professor Marshall Medoff (1945–2016), American economist Rafael Medoff (born c. 1959), American historian