Huffer is a surname. Notable people with the surname include:
Charles M. Huffer (1894–1981), American astronomer and academic Craig Huffer (born 1989), Australian middle-distance runner Fred K. Huffer (1879–1943), American composer and conductor Karin P. Huffer, American family therapist Lynne Huffer (born 1960), American feminist Sally Huffer (born 1965), American activist
See also Hermann Hüffer (1830–1905), German historian and jurist