16-Methylene-17α-hydroxyprogesterone acetate is a progestin of the 17α-hydroxyprogesterone group which was never marketed. Given orally, it shows about 2.5-fold the progestogenic activity of parenteral progesterone in animal bioassays. It is a parent compound of the following clinically used progestins:
Chlormethenmadinone acetate (6-chloro-16-methylene-17α-hydroxy-Δ6-progesterone acetate) Melengestrol acetate (6-methyl-16-methylene-17α-hydroxy-Δ6-progesterone acetate) Methenmadinone acetate (16-methylene-17α-hydroxy-Δ6-progesterone acetate) Segesterone acetate (16-methylene-17α-hydroxy-19-norprogesterone acetate)
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