De Franquetot is a surname. Notable people with the surname include:
Robert Jean Antoine de Franquetot de Coigny (1652–1704), French army officer, 2nd Count of Coigny François de Franquetot de Coigny (1670–1759), Marshal of France, 3rd Count and 1st Duke of Coigny François-Henri de Franquetot de Coigny (1737–1821), Marshal of France, 2nd Duke of Coigny Augustin-Gustave de Franquetot de Coigny (1788–1865), 3rd and last Duke of Coigny