Rome is a surname. Notable people with the surname include:
Aaron Rome (born 1983), Canadian professional ice hockey defenceman Adam Rome, American environmental historian Adolphe Rome (1889–1971), Belgian classical philologist and science historian Ashton Rome (born 1985), Canadian professional ice hockey winger David Rome (1910–1970), English cricketer Edith MacGregor Rome (died 1938), British nursing matron and administrator Esther Rome (1945–1995), American women's health activist and writer Francis Rome (1905–1985), Commandant of the British Sector in Berlin Harold Rome (1908–1993), American composer Jerry Rhome (born 1942), American football quarterback Jim Rome (born 1964), American sports radio talk show host Kevin D. Rome (born c. 1966), African-American university administrator Lewis Rome (1933–2015), American politician and university trustee Rangsiman Rome (born 1992), Thai politician and activist Richie Rome (1930–2020), American conductor and producer Sébastien Rome (born 1978), French politician Sydne Rome (born 1951), American actress
Fictional people Tony Rome, neo-noir detective