Semmes is a surname. Notable people with it include:
Albert G. Semmes (1810–1883), American lawyer and politician Alexander Alderman Semmes (1825–1885), American Civil War Union Navy commodore Benedict J. Semmes, Jr. (1913–1994), United States Navy admiral Benedict Joseph Semmes (1789–1863), American politician and Maryland State Senator Bernard B. Semmes, a mayor of Newport News, Virginia Paul Jones Semmes (1815–1863), a banker, businessman, and a Confederate General in the American Civil War Raphael Semmes (1809–1877), an officer in both the U.S. Navy and Confederate Navy Stephen Semmes, a Professor of Mathematics at Rice University Thomas J. Semmes (1824–1899), a member of the Louisiana state legislature T. Semmes Walmsley (1889–1942), Mayor of New Orleans