Jesse is a surname. Notable people with the surname include:
Eckhard Jesse (born 1948), German political scientist Edward Jesse (1780–1868), English writer on natural history John Heneage Jesse (1809–1874), English historian John John Jesse (born 1969), American painter Richard Henry Jesse (1853–1921), American educator, president of the University of Missouri F. Tennyson Jesse (1888–1958), English criminologist, journalist and author
See also Jessye, given name and surname