DeFazio may refer to:
Brandon DeFazio (born 1988), Canadian ice hockeyer Candy DeFazio (born 1950), United States lawn bowler David DeFazio (born 1983), American-born ice dancer Dean DeFazio (born 1963), Canadian ice hockey forward Johnny DeFazio (1940–2021), American professional wrestler Peter DeFazio (born 1947), representative from Oregon's 4th congressional district
See also Fazio (surname), list of people with a similar surname