DeGraffenreid is a surname. Notable people with the surname include:
Allen DeGraffenreid (wide receiver) (born 1970), American football player Allen DeGraffenreid (offensive lineman) (born 1974), American football player Emma DeGraffenreid, plaintiff of a 1976 employment discrimination lawsuit cited in the development of the theory of intersectionality Gordon DeGraffenreid, American football coach James DeGraffenreid, Nevada Republican Party Executive Board member and defendant in State of Nevada v. Michael J. McDonald, et al. Kenneth E. deGraffenreid, American university professor Reese C. De Graffenreid (1859–1902), American politician from Texas Veronica Degraffenreid, Secretary of the Commonwealth of Pennsylvania beginning in 2021