Loyzaga is a Spanish surname. Notable people with the surname include:
Bing Loyzaga (born 1970), Filipino actress Carlos Loyzaga (1930–2016), Filipino basketball player and coach Chito Loyzaga (born 1958), Filipino basketball player Diego Loyzaga (born 1995), Filipino actor Joaquín Loyzaga, Filipino footballer Joey Loyzaga (born 1961), Filipino basketball player Jorge Loyzaga, Mexican architect , Spanish sculptor